Quantitative methods to measure aneuploidy and chromosomal instability. Zhao Y, Carter R, Natarajan S, Varn FS, Compton DA, Gawad C, Cheng C, Godek KMīMC Med Genomics. Single-cell RNA sequencing reveals the impact of chromosomal instability on glioblastoma cancer stem cells. Epub 2020 Feb 24.Ĭhromosomal instability suppresses the growth of K-Ras-induced lung adenomas.Ĭell Cycle. doi: 10.1007/978-1-0716-1904-9_13.Ī comparative analysis of methods to measure kinetochore-microtubule attachment stability. Identifying Cyclin A/Cdk1 Substrates in Mitosis in Human Cells. Kucharski TJ, Hards R, Vandal SE, Abad MA, Jeyaprakash AA, Kaye E, Al-Rawi A, Ly T, Godek KM, Gerber SA, Compton DA Small changes in phospho-occupancy at the kinetochore-microtubule interface drive mitotic fidelity. Duane has mentored 13 graduate students to the completion of their PhDs.ĭuane would be happy to mentor faculty about teaching in large or small group environments, directing a course, and mentoring graduate students. He served as course director for that course for many years. Duane also contributed lectures to Biochem 103, the third term of the MCB core course for first year graduate students. He served as course director for Biochem 110 for many years. Current work is aimed at how this process is regulated during the cell cycle and at how these proteins coordinate chromosome movement during cell division.ĭuane has contributed lectures and small group discussions to Biochem 110, the Biochemical and Genetic Basis of Medicine, for first year medical students. This work has led to the characterization of both structural and motor proteins that are necessary for the organization of the microtubules into spindles during mitosis and meiosis. Using both in vitro and in vivo approaches, the assembly and function of the microtubule-based spindle is being dissected at the molecular level. Work in this lab is aimed at understanding how chromosomes segregate efficiently during mitosis and meiosis in vertebrate cells.
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